Research Scholar, Metabolomics

Experimental Consultation and Design:

• Serve as the point of contact for client inquiries in the area of small molecule analysis by targeted and untargeted metabolomics, including lipidomics.
• Provide expert advice on experimental design, including selection of sample preparation techniques and analytical methods, to ensure methodological rigor and feasibility.
• Collaborate with other staff members to develop and optimize metabolomics experimental protocols.
• Stay abreast of the latest advances in analytical methods and techniques to integrate into research projects.

Sample Preparation and Acquisition:

• Perform liquid, liquid-liquid, or SPE extraction, derivatization, and other pre-analytical steps to ensure sample integrity and suitability for downstream analysis.
• Operate and maintain LC-MS metabolomics instrumentation (e.g. Thermo TSQ Altis Triple Quadrupole, Exploris 240, Exploris 480, ID-X).
• Develop and implement standard operating procedures (SOPs) for sample handling and preparation to ensure consistency across studies.

Data Analysis and Interpretation:

• Perform metabolomics studies and report the results (analyte peak area or concentrations) using relevant software such as Skyline, MS-Dial, and Compound Discoverer.
• Use appropriate statistical and bioinformatics tools to extract meaningful biological insights.
• Perform pathway analysis using specialized software and databases, as needed.
• Interpret complex datasets and collaborate with researchers to contextualize findings within the scope of the project.
• Prepare detailed reports and visualizations of data for internal review, publication in scientific journals, and in grant applications.

Administrative Responsibilities:

• Maintain accurate and up-to-date laboratory records, including experimental protocols, data logs, and inventory of samples and reagents.
• Coordinate with the operations manager to ensure adequate supplies; ensure continuity of operations by coordinating maintenance of major instrumentation and associated ancillary equipment.
• Assist in the training and supervision of staff and students in metabolomics techniques and best practices.
• Contribute to the preparation of manuscripts, grant applications, and progress reports for funding agencies.
• Ensure compliance with institutional and regulatory requirements related to biosafety, data management, and ethical standards.